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Managing Partner

Sal DeTrane co-founded Empactful Capital with a penchant for strategy, growth planning and operational execution, skill which he honed over his 25 years of experience spanning roles in venture capital, business development, organizational development, operations, and finance.

Sal’s passion for advising technology-focused, early and growth stage entrepreneurs came into focus when he moved to Silicon Valley in 1996. In late 2001, he co-founded Nucleus Partners to serve as a venture capital and catalyst firm for seed and early-stage technology businesses – it was here that Sal pioneered the approach of a “working engagement” diligence model. Sal led Nucleus’ investment in Mede Analytics, the nation’s largest privately held health care analytics business, a company which he went on to run for 12 years as the #2 executive. During this time, Sal gained valuable direct P&L and operational experience. He was instrumental in Mede’s revenue growth in both the hospital and payer markets. This market/product strategy led to Mede’s growth from $3 million to over $120 million in revenues. Thoma Bravo acquired Mede as it prepared for its IPO in 2015.

Prior to Nucleus, Sal co-managed nearly $50 million of committed capital at The Angels’ Forum after successfully building a technology investment banking practice in Silicon Valley.

Bolstered by a history of developing and managing relationships across the healthcare ecosystem, Sal sits on the boards of several early/growth stage healthcare IT companies.

A die-hard Philly sports fan, Sal currently splits his time between Bucks County, PA and the Bay Area. Sal graduated Summa Cum Laude with his B.S. in Business Administration, with an emphasis in Accounting, from Temple University. Sal currently serves on Temple University’s President’s Council and the Dean’s Council for the Fox Business School where he is also assisting with the development of a Venture Capital and Private Equity Institute.

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